What is IGF-1?
Insulin-like growth factor-1, or IGF-1, is a hormonal mediator of statural growth. Mecasermin is human IGF-1 produced using recombinant DNA technology. INCRELEX prescribing information.
Who is INCRELEX indicated for?
The US INCRELEX label indicates treatment of growth failure in pediatric patients aged 2 years or older with severe primary IGF-1 deficiency, or with a growth hormone gene deletion who have developed neutralizing antibodies to growth hormone. INCRELEX prescribing information.
INCRELEX and severe low blood sugar
Severe hypoglycemia leading to hypoglycemic seizures has been observed with INCRELEX treatment. INCRELEX prescribing information.
Is INCRELEX a substitute for growth hormone?
The label states that INCRELEX is not a substitute for growth hormone for approved growth-hormone indications. The biological relationship between IGF-1 and growth does not make the medicines interchangeable. For the separate growth-hormone topic, see somatropin and the growth-hormone overview. INCRELEX prescribing information.
